Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort

BACKGROUND: We report the clinical activity and safety of bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of the transforming growth factor β (TGF-β)RII receptor (a TGF-β ‘trap’) fused to a human IgG1 monoclonal antibody blocking programmed death-li...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Immunother Cancer
Autores principales: Cho, Byoung Chul, Daste, Amaury, Ravaud, Alain, Salas, Sébastien, Isambert, Nicolas, McClay, Edward, Awada, Ahmad, Borel, Christian, Ojalvo, Laureen S, Helwig, Christoph, Rolfe, P Alexander, Gulley, James L, Penel, Nicolas
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2020
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342865/
https://ncbi.nlm.nih.gov/pubmed/32641320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000664
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares