Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma

BACKGROUND: For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy plus temozolomide. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) fused to...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Khasraw, Mustafa, Weller, Michael, Lorente, David, Kolibaba, Kathryn, Lee, Chee Khoon, Gedye, Craig, I. de La Fuente, Macarena, Vicente, David, Reardon, David A, Gan, Hui K, Scott, Andrew M, Dussault, Isabelle, Helwig, Christoph, Ojalvo, Laureen S, Gourmelon, Carole, Groves, Morris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156979/
https://ncbi.nlm.nih.gov/pubmed/34056607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab058
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