Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma

BACKGROUND: For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy plus temozolomide. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) fused to...

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Bibliografiske detaljer
Udgivet i:Neurooncol Adv
Main Authors: Khasraw, Mustafa, Weller, Michael, Lorente, David, Kolibaba, Kathryn, Lee, Chee Khoon, Gedye, Craig, I. de La Fuente, Macarena, Vicente, David, Reardon, David A, Gan, Hui K, Scott, Andrew M, Dussault, Isabelle, Helwig, Christoph, Ojalvo, Laureen S, Gourmelon, Carole, Groves, Morris
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Clinical Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156979/
https://ncbi.nlm.nih.gov/pubmed/34056607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab058
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