Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer

BACKGROUND: Patients with biliary tract cancer (BTC) have poor prognosis with few treatment options. Bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of the transforming growth factor (TGF)-βRII receptor (a TGF-β ‘trap’) fused to a human IgG1 antibod...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Yoo, Changhoon, Oh, Do-Youn, Choi, Hye Jin, Kudo, Masatoshi, Ueno, Makoto, Kondo, Shunsuke, Chen, Li-Tzong, Osada, Motonobu, Helwig, Christoph, Dussault, Isabelle, Ikeda, Masafumi
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254161/
https://ncbi.nlm.nih.gov/pubmed/32461347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000564
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