Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

The (m7)G cap is ubiquitous on RNAPII-transcribed RNA and has fundamental roles in eukaryotic gene expression, however its in vivo role in mammals has remained unknown. Here, we identified the (m7)G cap methyltransferase, RNMT, as a key mediator of T cell activation, which specifically regulates rib...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Galloway, Alison, Kaskar, Aneesa, Ditsova, Dimitrinka, Atrih, Abdelmadjid, Yoshikawa, Harunori, Gomez-Moreira, Carolina, Suska, Olga, Warminski, Marcin, Grzela, Renata, Lamond, Angus I, Darzynkiewicz, Edward, Jemielity, Jacek, Cowling, Victoria H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266598/
https://ncbi.nlm.nih.gov/pubmed/34125914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab465
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