Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM

Maturation and translation of mRNA in eukaryotes requires the addition of the 7-methylguanosine cap. In vertebrates, the cap methyltransferase, RNA guanine-7 methyltransferase (RNMT), has an activating subunit, RNMT-Activating Miniprotein (RAM). Here we report the first crystal structure of the huma...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Varshney, Dhaval, Petit, Alain-Pierre, Bueren-Calabuig, Juan A., Jansen, Chimed, Fletcher, Dan A., Peggie, Mark, Weidlich, Simone, Scullion, Paul, Pisliakov, Andrei V., Cowling, Victoria H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137418/
https://ncbi.nlm.nih.gov/pubmed/27422871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw637
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