Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts

The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being investigated for their role in diseases and as potential therapeutic targets. The intermediate sphingolipids such as dihydrosphingosine (dhSph) and sphingosine (Sph) hav...

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Bibliographic Details
Published in:Int J Cardiol Heart Vasc
Main Authors: Magaye, Ruth R., Savira, Feby, Xiong, Xin, Huynh, Kevin, Meikle, Peter J., Reid, Christopher, Flynn, Bernard L., Kaye, David, Liew, Danny, Wang, Bing H.
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264607/
https://ncbi.nlm.nih.gov/pubmed/34277924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcha.2021.100837
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