HGG-42. PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) SHOWS ROBUST RESPONSE TO IMIPRIDONE BASED COMBINATION THERAPY

ONC201 is a first-in-class small molecule imipridone therapy, which is known to selectively induce apoptosis of cancer cells independent of p53. This novel chemotherapeutic, as well as its analogs ONC206 and ONC212, has been shown to have potent preclinical efficacy against H3K27M mutant diffuse int...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-i, Zhang, Yiqun, Prabhu, Varun, Allen, Joshua, Tapinos, Nikos, Lulla, Rishi, El-Deiry, Wafik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2021
Onderwerpen:
High Grade Gliomas
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263206/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.106
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