HGG-42. PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) SHOWS ROBUST RESPONSE TO IMIPRIDONE BASED COMBINATION THERAPY

ONC201 is a first-in-class small molecule imipridone therapy, which is known to selectively induce apoptosis of cancer cells independent of p53. This novel chemotherapeutic, as well as its analogs ONC206 and ONC212, has been shown to have potent preclinical efficacy against H3K27M mutant diffuse int...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:Neuro Oncol
Główni autorzy: Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-i, Zhang, Yiqun, Prabhu, Varun, Allen, Joshua, Tapinos, Nikos, Lulla, Rishi, El-Deiry, Wafik
Format: Artigo
Język:Inglês
Wydane: Oxford University Press 2021
Hasła przedmiotowe:
High Grade Gliomas
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263206/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.106
Etykiety: Dodaj etykietę
Nie ma etykietki, Dołącz pierwszą etykiete!

Podobne zapisy