HGG-42. PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) SHOWS ROBUST RESPONSE TO IMIPRIDONE BASED COMBINATION THERAPY

ONC201 is a first-in-class small molecule imipridone therapy, which is known to selectively induce apoptosis of cancer cells independent of p53. This novel chemotherapeutic, as well as its analogs ONC206 and ONC212, has been shown to have potent preclinical efficacy against H3K27M mutant diffuse int...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-i, Zhang, Yiqun, Prabhu, Varun, Allen, Joshua, Tapinos, Nikos, Lulla, Rishi, El-Deiry, Wafik
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
High Grade Gliomas
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263206/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.106
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