HGG-42. PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) SHOWS ROBUST RESPONSE TO IMIPRIDONE BASED COMBINATION THERAPY

ONC201 is a first-in-class small molecule imipridone therapy, which is known to selectively induce apoptosis of cancer cells independent of p53. This novel chemotherapeutic, as well as its analogs ONC206 and ONC212, has been shown to have potent preclinical efficacy against H3K27M mutant diffuse int...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-i, Zhang, Yiqun, Prabhu, Varun, Allen, Joshua, Tapinos, Nikos, Lulla, Rishi, El-Deiry, Wafik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
High Grade Gliomas
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263206/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.106
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