HGG-42. PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) SHOWS ROBUST RESPONSE TO IMIPRIDONE BASED COMBINATION THERAPY

ONC201 is a first-in-class small molecule imipridone therapy, which is known to selectively induce apoptosis of cancer cells independent of p53. This novel chemotherapeutic, as well as its analogs ONC206 and ONC212, has been shown to have potent preclinical efficacy against H3K27M mutant diffuse int...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-i, Zhang, Yiqun, Prabhu, Varun, Allen, Joshua, Tapinos, Nikos, Lulla, Rishi, El-Deiry, Wafik
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
High Grade Gliomas
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263206/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.106
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker