DIPG-62. PRECLINICAL EVALUATION OF IMIPRIDONE-BASED COMBINATION THERAPIES IN PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Imipridones induce apoptosis in cancer via p53 independent upregulation of TNF-related apoptosis inducing ligand (TRAIL) pathway and its proapoptotic receptor DR5. ONC201, a first-in-class imipridone, is being evaluated alone and with radiotherapy for children with H3K27M mutant diffuse glioma. We s...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Borsuk, Robyn, Zhou, Lanlan, Zhang, Yiqun, Prabhua, Varun, Allen, Joshua, Oster, Wolfgang, Tapinos, Nikos, Lulla, Rishi R, El-Deiry, Wafik
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Diffuse Midline Glioma/DIPG
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715116/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.107
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