The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer

Despite the availability of multiple human epidermal growth factor receptor 2–targeted (HER2-targeted) treatments, therapeutic resistance in HER2(+) breast cancer remains a clinical challenge. Intratumor heterogeneity for HER2 and resistance-conferring mutations in the PIK3CA gene (encoding PI3K cat...

詳細記述

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書誌詳細
出版年:JCI Insight
主要な著者: Janiszewska, Michalina, Stein, Shayna, Metzger Filho, Otto, Eng, Jennifer, Kingston, Natalie L., Harper, Nicholas W., Rye, Inga H., Alečković, Maša, Trinh, Anne, Murphy, Katherine C., Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P., Krop, Ian E., Russnes, Hege G., Spellman, Paul T., Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W., Michor, Franziska, Polyak, Kornelia
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2021
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262355/
https://ncbi.nlm.nih.gov/pubmed/33886505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147617
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