The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer

Despite the availability of multiple human epidermal growth factor receptor 2–targeted (HER2-targeted) treatments, therapeutic resistance in HER2(+) breast cancer remains a clinical challenge. Intratumor heterogeneity for HER2 and resistance-conferring mutations in the PIK3CA gene (encoding PI3K cat...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Janiszewska, Michalina, Stein, Shayna, Metzger Filho, Otto, Eng, Jennifer, Kingston, Natalie L., Harper, Nicholas W., Rye, Inga H., Alečković, Maša, Trinh, Anne, Murphy, Katherine C., Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P., Krop, Ian E., Russnes, Hege G., Spellman, Paul T., Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W., Michor, Franziska, Polyak, Kornelia
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262355/
https://ncbi.nlm.nih.gov/pubmed/33886505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147617
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares