The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer

Despite the availability of multiple human epidermal growth factor receptor 2–targeted (HER2-targeted) treatments, therapeutic resistance in HER2(+) breast cancer remains a clinical challenge. Intratumor heterogeneity for HER2 and resistance-conferring mutations in the PIK3CA gene (encoding PI3K cat...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Janiszewska, Michalina, Stein, Shayna, Metzger Filho, Otto, Eng, Jennifer, Kingston, Natalie L., Harper, Nicholas W., Rye, Inga H., Alečković, Maša, Trinh, Anne, Murphy, Katherine C., Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P., Krop, Ian E., Russnes, Hege G., Spellman, Paul T., Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W., Michor, Franziska, Polyak, Kornelia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262355/
https://ncbi.nlm.nih.gov/pubmed/33886505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147617
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