The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer

Despite the availability of multiple human epidermal growth factor receptor 2–targeted (HER2-targeted) treatments, therapeutic resistance in HER2(+) breast cancer remains a clinical challenge. Intratumor heterogeneity for HER2 and resistance-conferring mutations in the PIK3CA gene (encoding PI3K cat...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Janiszewska, Michalina, Stein, Shayna, Metzger Filho, Otto, Eng, Jennifer, Kingston, Natalie L., Harper, Nicholas W., Rye, Inga H., Alečković, Maša, Trinh, Anne, Murphy, Katherine C., Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P., Krop, Ian E., Russnes, Hege G., Spellman, Paul T., Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W., Michor, Franziska, Polyak, Kornelia
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262355/
https://ncbi.nlm.nih.gov/pubmed/33886505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147617
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