Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function

The cap-binding protein eukaryotic initiation factor 4E (eIF4E) promotes translation of mRNAs associated with proliferation and survival and is an attractive target for cancer therapeutics. Here, we used Eif4e germline and conditional knockout models to assess the impact of reduced Eif4e gene dosage...

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Détails bibliographiques
Publié dans:iScience
Auteurs principaux: Chiu, Honyin, Buono, Roberta, Jackson, Leandra V., Herzog, Lee-or, Mallya, Sharmila, Conn, Crystal S., Ruggero, Davide, Fruman, David A.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261676/
https://ncbi.nlm.nih.gov/pubmed/34278258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102748
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