The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation

The class I phosphoinoside-3-kinases (PI3Ks) are important enzymes that relay signals from cell surface receptors to downstream mediators driving cellular functions. Elevated PI3K signaling is found in B cell malignancies and lymphocytes of patients with autoimmune disease. The p110δ catalytic isofo...

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Detalhes bibliográficos
Publicado no:Front Immunol
Principais autores: Chiu, Honyin, Mallya, Sharmila, Nguyen, Phuongthao, Mai, Annie, Jackson, Leandra V., Winkler, David G., DiNitto, Jonathan P., Brophy, Erin E., McGovern, Karen, Kutok, Jeffery L., Fruman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491903/
https://ncbi.nlm.nih.gov/pubmed/28713374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00747
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