IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells

Chronic lymphocytic leukemia (CLL) displays constitutive phosphatidylinositol 3-kinase (PI3K) activation resulting from aberrant regulation of B-cell receptor (BCR) signaling. Previous studies have shown that an oral PI3K p110δ inhibitor idelalisib exhibits promising activity in CLL. Here, we demons...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood
मुख्य लेखकों: Dong, Shuai, Guinn, Daphne, Dubovsky, Jason A., Zhong, Yiming, Lehman, Amy, Kutok, Jeffery, Woyach, Jennifer A., Byrd, John C., Johnson, Amy J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2014
विषय:
Lymphoid Neoplasia
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256910/
https://ncbi.nlm.nih.gov/pubmed/25258342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-587279
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