OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells

Aberrant regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic leukemia (CLL). Signaling via conjugation of surface receptors within the tumor environmental niche activates survival and proliferation pathways in CLL. Of these, the phosphoinositide 3-kina...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Liu, Ta-Ming, Ling, Yonghua, Woyach, Jennifer A., Beckwith, Kyle, Yeh, Yuh-Ying, Hertlein, Erin, Zhang, Xiaoli, Lehman, Amy, Awan, Farrukh, Jones, Jeffrey A., Andritsos, Leslie A., Maddocks, Kami, MacMurray, Jessica, Salunke, Santosh B., Chen, Ching-Shih, Phelps, Mitch A., Byrd, John C., Johnson, Amy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287637/
https://ncbi.nlm.nih.gov/pubmed/25293770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583518
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados