OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells

Aberrant regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic leukemia (CLL). Signaling via conjugation of surface receptors within the tumor environmental niche activates survival and proliferation pathways in CLL. Of these, the phosphoinositide 3-kina...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Liu, Ta-Ming, Ling, Yonghua, Woyach, Jennifer A., Beckwith, Kyle, Yeh, Yuh-Ying, Hertlein, Erin, Zhang, Xiaoli, Lehman, Amy, Awan, Farrukh, Jones, Jeffrey A., Andritsos, Leslie A., Maddocks, Kami, MacMurray, Jessica, Salunke, Santosh B., Chen, Ching-Shih, Phelps, Mitch A., Byrd, John C., Johnson, Amy J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287637/
https://ncbi.nlm.nih.gov/pubmed/25293770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583518
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