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The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes
Rapamycin has been used as a clinical immunosuppressant for many years; however, the molecular basis for its selective effects on lymphocytes remains unclear. We investigated the role of two canonical effectors of the mammalian target of rapamycin (mTOR), ribosomal S6 kinases (S6Ks) and eukaryotic i...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4924540/ https://ncbi.nlm.nih.gov/pubmed/27245614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad8463 |
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