The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

Rapamycin has been used as a clinical immunosuppressant for many years; however, the molecular basis for its selective effects on lymphocytes remains unclear. We investigated the role of two canonical effectors of the mammalian target of rapamycin (mTOR), ribosomal S6 kinases (S6Ks) and eukaryotic i...

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Publicat a:Sci Signal
Autors principals: So, Lomon, Lee, Jongdae, Palafox, Miguel, Mallya, Sharmila, Woxland, Chaz G., Arguello, Meztli, Truitt, Morgan L., Sonenberg, Nahum, Ruggero, Davide, Fruman, David A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924540/
https://ncbi.nlm.nih.gov/pubmed/27245614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad8463
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