Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage. The influence of the linkages on the self-assembly, in vivo fate and ant...

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Vydáno v:Asian J Pharm Sci
Hlavní autoři: Li, Lingxiao, Zuo, Shiyi, Dong, Fudan, Liu, Tian, Gao, Yanlin, Yang, Yinxian, Wang, Xin, Sun, Jin, Sun, Bingjun, He, Zhonggui
Médium: Artigo
Jazyk:Inglês
Vydáno: Shenyang Pharmaceutical University 2021
Témata:
Original Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261084/
https://ncbi.nlm.nih.gov/pubmed/34276822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2021.02.002
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