Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Rational design of nanoparticulate drug delivery systems (nano-DDS) for efficient cancer therapy is still a challenge, restricted by poor drug loading, poor stability, and poor tumor selectivity. Here, we report that simple insertion of a trisulfide bond can turn doxorubicin homodimeric prodrugs int...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Yang, Yinxian, Sun, Bingjun, Zuo, Shiyi, Li, Ximu, Zhou, Shuang, Li, Lingxiao, Luo, Cong, Liu, Hongzhuo, Cheng, Maosheng, Wang, Yongjun, Wang, Shujun, He, Zhonggui, Sun, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673695/
https://ncbi.nlm.nih.gov/pubmed/33148644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc1725
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