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Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage. The influence of the linkages on the self-assembly, in vivo fate and ant...

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Detalhes bibliográficos
Principais autores: Lingxiao Li, Shiyi Zuo, Fudan Dong, Tian Liu, Yanlin Gao, Yinxian Yang, Xin Wang, Jin Sun, Bingjun Sun, Zhonggui He
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Communications Co., Ltd. 2021-05-01
coleção:Asian Journal of Pharmaceutical Sciences
Assuntos:
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1818087621000155
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