Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma

Activating KRAS mutations, a defining feature of pancreatic ductal adenocarcinoma (PDAC), promote tumor growth in part through the activation of cyclin-dependent kinases (CDKs) that induce cell cycle progression. p16(INK4a) (p16), encoded by the gene CDKN2A, is a potent inhibitor of CDK4/6 and serve...

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Publicado en:Mol Cancer Ther
Main Authors: Willobee, Brent A., Gaidarski, Alexander A., Dosch, Austin R., Castellanos, Jason A., Dai, Xizi, Mehra, Siddharth, Messaggio, Fanuel, Srinivasan, Supriya, VanSaun, Michael N., Nagathihalli, Nagaraj S., Merchant, Nipun B.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260447/
https://ncbi.nlm.nih.gov/pubmed/34001634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-1043
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