Identification and initial characterization of a potent inhibitor of ferroptosis

Ferroptosis is a form of iron-dependent cell death characterized by elevated lipid peroxides and reactive oxygen species (ROS). Glutathione (GSH) plays an essential role in scavenging ROS to maintain cell viability, and acts as a cofactor of GSH peroxidase 4 (GPX4) that protects lipids from oxidatio...

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Bibliografiske detaljer
Udgivet i:J Cell Biochem
Main Authors: Kuganesan, Nishanth, Dlamini, Samkeliso, McDaniel, Jade, Tillekeratne, Viranga LM, Taylor, William R
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259732/
https://ncbi.nlm.nih.gov/pubmed/33377232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.29870
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