Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling

The epidermal growth factor receptor (EGFR) is a membrane-anchored tyrosine kinase that is able to selectively respond to multiple extracellular stimuli. Previous studies have indicated that the modularity of this system may be caused by ligand-induced differences in the stability of the receptor di...

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Sparad:
Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Pascarelli, Stefano, Merzhakupova, Dalmira, Uechi, Gen-Ichiro, Laurino, Paola
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259408/
https://ncbi.nlm.nih.gov/pubmed/34126069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100872
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