Mouse Embryonic Stem Cells Expressing GDNF Show Enhanced Dopaminergic Differentiation and Promote Behavioral Recovery After Grafting in Parkinsonian Rats

Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic neurons (DaNs) of the substantia nigra pars compacta and the decrease of dopamine in the brain. Grafting DaN differentiated from embryonic stem cells (ESCs) has been proposed as an alternative therapy for curr...

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Detalles Bibliográficos
Publicado en:Front Cell Dev Biol
Main Authors: Lara-Rodarte, Rolando, Cortés, Daniel, Soriano, Karla, Carmona, Francia, Rocha, Luisa, Estudillo, Enrique, López-Ornelas, Adolfo, Velasco, Iván
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258349/
https://ncbi.nlm.nih.gov/pubmed/34239871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.661656
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