Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration

Intervertebral disc degeneration (IDD) is the primary cause of low back pain. Stress-induced DNA damage is closely relevant to the pathogenesis of IDD; however, the underlying mechanisms remain unclear. This study investigated the role of the absent in melanoma 2 (AIM2) inflammasome as a DNA damage...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Li, Shuai, Liao, Zhiwei, Luo, Rongjin, Song, Yu, Wang, Kun, Feng, Xiaobo, Ou, Yangliu, Wu, Xinghuo, Zhang, Yukun, Gao, Yong, Yin, Huipeng, Yang, Cao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258158/
https://ncbi.nlm.nih.gov/pubmed/34239872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.672847
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