Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration

OBJECTIVE: Lactate accumulation is an important factor in the intervertebral disc degeneration (IVDD). Currently, the effect and underlying mechanism of action of lactate on nucleus pulposus (NP) cell inflammation during IVDD are unclear. Previous studies have found that the NLRP3 inflammasome plays...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Zhao, Kangcheng, An, Ran, Xiang, Qian, Li, Gaocai, Wang, Kun, Song, Yu, Liao, Zhiwei, Li, Shuai, Hua, Wenbin, Feng, Xiaobo, Wu, Xinghuo, Zhang, Yukun, Das, Abhirup, Yang, Cao
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791185/
https://ncbi.nlm.nih.gov/pubmed/33111436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12941
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