Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration

OBJECTIVE: Lactate accumulation is an important factor in the intervertebral disc degeneration (IVDD). Currently, the effect and underlying mechanism of action of lactate on nucleus pulposus (NP) cell inflammation during IVDD are unclear. Previous studies have found that the NLRP3 inflammasome plays...

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Vydáno v:Cell Prolif
Hlavní autoři: Zhao, Kangcheng, An, Ran, Xiang, Qian, Li, Gaocai, Wang, Kun, Song, Yu, Liao, Zhiwei, Li, Shuai, Hua, Wenbin, Feng, Xiaobo, Wu, Xinghuo, Zhang, Yukun, Das, Abhirup, Yang, Cao
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791185/
https://ncbi.nlm.nih.gov/pubmed/33111436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12941
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