Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo

Intervertebral disc degeneration (IDD) is the primary culprit of low back pain and renders heavy social burden worldwide. Pyroptosis is a newly discovered form of programmed cell death, which is also involved in nucleus pulposus (NP) cells during IDD progression. Moderate autophagy activity is criti...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Liao, Zhiwei, Li, Suyun, Liu, Rong, Feng, Xiaobo, Shi, Yunsong, Wang, Kun, Li, Shuai, Zhang, Yukun, Wu, Xinghuo, Yang, Cao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238599/
https://ncbi.nlm.nih.gov/pubmed/34239691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/5584447
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