USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription

Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer. However, the underlying mechanisms of radioresistance remain elusive. Here, we show that lysine-specific demethylase 4C (KDM4C) is overexpressed and correlated with poor prognosis in lung cancer patients. We pr...

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Pubblicato in:Cell Death Differ
Autori principali: Jie, Xiaohua, Fong, William Pat, Zhou, Rui, Zhao, Ye, Zhao, Yingchao, Meng, Rui, Zhang, Sheng, Dong, Xiaorong, Zhang, Tao, Yang, Kunyu, Wu, Gang, Xu, Shuangbing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257660/
https://ncbi.nlm.nih.gov/pubmed/33558705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-021-00740-z
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