UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance

UBE2O, an E2/E3 hybrid ubiquitin-protein ligase, has been implicated in the regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its role in cancer radioresistance remains completely unknown. Here, we uncover that UBE2O interacts and targets Mxi1 for ubiquitinatio...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Huang, Yumei, Yang, Xijie, Lu, Yanwei, Zhao, Ye, Meng, Rui, Zhang, Sheng, Dong, Xiaorong, Xu, Shuangbing, Wu, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862231/
https://ncbi.nlm.nih.gov/pubmed/32901121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00616-8
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