UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance

UBE2O, an E2/E3 hybrid ubiquitin-protein ligase, has been implicated in the regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its role in cancer radioresistance remains completely unknown. Here, we uncover that UBE2O interacts and targets Mxi1 for ubiquitinatio...

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Publicado en:Cell Death Differ
Autores principales: Huang, Yumei, Yang, Xijie, Lu, Yanwei, Zhao, Ye, Meng, Rui, Zhang, Sheng, Dong, Xiaorong, Xu, Shuangbing, Wu, Gang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862231/
https://ncbi.nlm.nih.gov/pubmed/32901121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00616-8
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