β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer

Aberrant expression of FOXN2, a member of the Forkhead box transcription factors, has been found in several types of cancer. However, the underlying mechanisms of FOXN2 deregulation in tumorigenesis remain largely unknown. Here, we find that FOXN2 binds to and is ubiquitinated by β-Trcp ubiquitin li...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Death Differ
Päätekijät: Ma, Jia, Lu, Yanwei, Zhang, Sheng, Li, Yan, Huang, Jing, Yin, Zhongyuan, Ren, Jinghua, Huang, Kai, Liu, Li, Yang, Kunyu, Wu, Gang, Xu, Shuangbing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113220/
https://ncbi.nlm.nih.gov/pubmed/29396548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0055-6
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia