Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers

Several opioids are metabolized by the inducible cytochrome P450 (CYP) 3A isozymes. Coadministration with strong inducers of drug metabolism, such as rifampin, can dramatically reduce systemic exposure to these opioids. As the CYP metabolism of hydromorphone is of minor importance, we studied in hea...

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Bibliografiske detaljer
Udgivet i:Anesth Analg
Main Authors: Lohela, Terhi J., Poikola, Satu, Neuvonen, Mikko, Niemi, Mikko, Backman, Janne T., Olkkola, Klaus T., Lilius, Tuomas O.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkin 2020
Fag:
48
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257471/
https://ncbi.nlm.nih.gov/pubmed/33177323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005229
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