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Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers

Several opioids are metabolized by the inducible cytochrome P450 (CYP) 3A isozymes. Coadministration with strong inducers of drug metabolism, such as rifampin, can dramatically reduce systemic exposure to these opioids. As the CYP metabolism of hydromorphone is of minor importance, we studied in hea...

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Bibliografske podrobnosti
izdano v:Anesth Analg
Main Authors: Lohela, Terhi J., Poikola, Satu, Neuvonen, Mikko, Niemi, Mikko, Backman, Janne T., Olkkola, Klaus T., Lilius, Tuomas O.
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkin 2020
Teme:
48
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257471/
https://ncbi.nlm.nih.gov/pubmed/33177323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005229
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