Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome

Approximately 1% of the human genome has the ability to fold into G-quadruplexes (G4s)—noncanonical strand-specific DNA structures forming at G-rich motifs. G4s regulate several key cellular processes (e.g., transcription) and have been hypothesized to participate in others (e.g., firing of replicat...

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Publicat a:Genome Res
Autors principals: Guiblet, Wilfried M., DeGiorgio, Michael, Cheng, Xiaoheng, Chiaromonte, Francesca, Eckert, Kristin A., Huang, Yi-Fei, Makova, Kateryna D.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256861/
https://ncbi.nlm.nih.gov/pubmed/34187812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.269589.120
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