Deletion of Intestinal SHP Impairs Short-term Response to Cholic Acid Challenge in Male Mice

Small heterodimer partner (SHP) is a crucial regulator of bile acid (BA) transport and synthesis; however, its intestine-specific role is not fully understood. Here, we report that male intestine-specific Shp knockout (IShpKO) mice exhibit higher intestinal BA but not hepatic or serum BA levels comp...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Nguyen, James T, Riessen, Ryan, Zhang, Tongyu, Kieffer, Collin, Anakk, Sayeepriyadarshini
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256632/
https://ncbi.nlm.nih.gov/pubmed/33769482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqab063
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