Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes

Nuclear receptors Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP) are important regulators of bile acid, lipid and glucose homeostasis. Here we show that global Fxr (−/−) Shp(−/−) double knockout (DKO) mice are refractory to weight gain, glucose intolerance and hepatic steatosis when...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Akinrotimi, Oludemilade, Riessen, Ryan, VanDuyne, Philip, Park, Jung Eun, Lee, Yoon Kwang, Wong, Lee-Jun, Zavacki, Ann M, Schoonjans, Kristina, Anakk, Sayeepriyadarshini
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696047/
https://ncbi.nlm.nih.gov/pubmed/28586124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29305
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