Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis

Bile acid homeostasis is tightly regulated via a feedback loop operated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP). Contrary to current models, which place FXR upstream of SHP in a linear regulatory pathway, here we show that the phenotypic consequences i...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Anakk, Sayeepriyadarshini, Watanabe, Mitsuhiro, Ochsner, Scott A., McKenna, Neil J., Finegold, Milton J., Moore, David D.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007143/
https://ncbi.nlm.nih.gov/pubmed/21123943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42846
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires