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Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis
Bile acid homeostasis is tightly regulated via a feedback loop operated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP). Contrary to current models, which place FXR upstream of SHP in a linear regulatory pathway, here we show that the phenotypic consequences i...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3007143/ https://ncbi.nlm.nih.gov/pubmed/21123943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42846 |
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