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Lateral gate dynamics of the bacterial translocon during cotranslational membrane protein insertion

During synthesis of membrane proteins, transmembrane segments (TMs) of nascent proteins emerging from the ribosome are inserted into the central pore of the translocon (SecYEG in bacteria) and access the phospholipid bilayer through the open lateral gate formed of two helices of SecY. Here we use si...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Mercier, Evan, Wang, Xiaolin, Maiti, Manisankar, Wintermeyer, Wolfgang, Rodnina, Marina V.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256087/
https://ncbi.nlm.nih.gov/pubmed/34162707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100474118
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