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Lateral gate dynamics of the bacterial translocon during cotranslational membrane protein insertion

During synthesis of membrane proteins, transmembrane segments (TMs) of nascent proteins emerging from the ribosome are inserted into the central pore of the translocon (SecYEG in bacteria) and access the phospholipid bilayer through the open lateral gate formed of two helices of SecY. Here we use si...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Mercier, Evan, Wang, Xiaolin, Maiti, Manisankar, Wintermeyer, Wolfgang, Rodnina, Marina V.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256087/
https://ncbi.nlm.nih.gov/pubmed/34162707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100474118
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