Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing

High-acuity αβT cell receptor (TCR) recognition of peptides bound to major histocompatibility complex molecules (pMHCs) requires mechanosensing, a process whereby piconewton (pN) bioforces exert physical load on αβTCR–pMHC bonds to dynamically alter their lifetimes and foster digital sensitivity cel...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Mallis, Robert J., Duke-Cohan, Jonathan S., Das, Dibyendu Kumar, Akitsu, Aoi, Luoma, Adrienne M., Banik, Debasis, Stephens, Hannah M., Tetteh, Paul W., Castro, Caitlin D., Krahnke, Sophie, Hussey, Rebecca E., Lawney, Brian, Brazin, Kristine N., Reche, Pedro A., Hwang, Wonmuk, Adams, Erin J., Lang, Matthew J., Reinherz, Ellis L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256041/
https://ncbi.nlm.nih.gov/pubmed/34172580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023050118
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