Mechanosensing drives acuity of αβ T-cell recognition

T lymphocytes use surface [Formula: see text] T-cell receptors (TCRs) to recognize peptides bound to MHC molecules (pMHCs) on antigen-presenting cells (APCs). How the exquisite specificity of high-avidity T cells is achieved is unknown but essential, given the paucity of foreign pMHC ligands relativ...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Feng, Yinnian, Brazin, Kristine N., Kobayashi, Eiji, Mallis, Robert J., Reinherz, Ellis L., Lang, Matthew J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625899/
https://ncbi.nlm.nih.gov/pubmed/28811364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703559114
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