Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing

High-acuity αβT cell receptor (TCR) recognition of peptides bound to major histocompatibility complex molecules (pMHCs) requires mechanosensing, a process whereby piconewton (pN) bioforces exert physical load on αβTCR–pMHC bonds to dynamically alter their lifetimes and foster digital sensitivity cel...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Mallis, Robert J., Duke-Cohan, Jonathan S., Das, Dibyendu Kumar, Akitsu, Aoi, Luoma, Adrienne M., Banik, Debasis, Stephens, Hannah M., Tetteh, Paul W., Castro, Caitlin D., Krahnke, Sophie, Hussey, Rebecca E., Lawney, Brian, Brazin, Kristine N., Reche, Pedro A., Hwang, Wonmuk, Adams, Erin J., Lang, Matthew J., Reinherz, Ellis L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256041/
https://ncbi.nlm.nih.gov/pubmed/34172580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023050118
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