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Differential Sensitivity of Wild-Type and BRAF-Mutated Cells to Combined BRAF and Autophagy Inhibition

BRAF inhibitors are insufficient monotherapies for BRAF-mutated cancer; therefore, we investigated which inhibitory pathway would yield the most effective therapeutic approach when targeted in combination with BRAF inhibition. The oncogenic BRAF inhibitor, PLX4720, increased basal autophagic flux in...

詳細記述

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書誌詳細
出版年:Biomol Ther (Seoul)
主要な著者: Yeom, Hojin, Hwang, Sung-Hee, Han, Byeal-I, Lee, Michael
フォーマット: Artigo
言語:Inglês
出版事項: The Korean Society of Applied Pharmacology 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255135/
https://ncbi.nlm.nih.gov/pubmed/33551379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2020.203
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