BRAF mutation predicts sensitivity to MEK inhibition

The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase (ERK) is activated in most human tumours, often through gain-of-function mutations of RAS and RAF family members(1). Using small-molecule inhibitors of MEKand an integrated...

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Detalhes bibliográficos
Main Authors: Solit, David B., Garraway, Levi A., Pratilas, Christine A., Sawai, Ayana, Getz, Gad, Basso, Andrea, Ye, Qing, Lobo, Jose M., She, Yuhong, Osman, Iman, Golub, Todd R., Sebolt-Leopold, Judith, Sellers, William R., Rosen, Neal
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306236/
https://ncbi.nlm.nih.gov/pubmed/16273091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04304
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