AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation

BACKGROUND: The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific transcriptional programs remain unknown. RESULTS: We employed a proteomic approach...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Epigenetics Chromatin
Egile Nagusiak: Uğurlu-Çimen, Deniz, Odluyurt, Deniz, Sevinç, Kenan, Özkan-Küçük, Nazlı Ezgi, Özçimen, Burcu, Demirtaş, Deniz, Enüstün, Eray, Aztekin, Can, Philpott, Martin, Oppermann, Udo, Özlü, Nurhan, Önder, Tamer T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2021
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254283/
https://ncbi.nlm.nih.gov/pubmed/34215314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-021-00406-7
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