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Optimizing subgroup selection in two‐stage adaptive enrichment and umbrella designs

We design two‐stage confirmatory clinical trials that use adaptation to find the subgroup of patients who will benefit from a new treatment, testing for a treatment effect in each of two disjoint subgroups. Our proposal allows aspects of the trial, such as recruitment probabilities of each group, to...

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Bibliografische gegevens
Gepubliceerd in:Stat Med
Hoofdauteurs: Ballarini, Nicolás M., Burnett, Thomas, Jaki, Thomas, Jennison, Christoper, König, Franz, Posch, Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251960/
https://ncbi.nlm.nih.gov/pubmed/33783020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8949
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