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Optimized adaptive enrichment designs
Based on a Bayesian decision theoretic approach, we optimize frequentist single- and adaptive two-stage trial designs for the development of targeted therapies, where in addition to an overall population, a pre-defined subgroup is investigated. In such settings, the losses and gains of decisions can...
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| Pubblicato in: | Stat Methods Med Res |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
SAGE Publications
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6613177/ https://ncbi.nlm.nih.gov/pubmed/29254436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280217747312 |
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