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Adaptive designs for subpopulation analysis optimizing utility functions

If the response to treatment depends on genetic biomarkers, it is important to identify predictive biomarkers that define (sub-)populations where the treatment has a positive benefit risk balance. One approach to determine relevant subpopulations are subgroup analyses where the treatment effect is e...

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Detalhes bibliográficos
Publicado no:Biom J
Main Authors: Graf, Alexandra C, Posch, Martin, Koenig, Franz
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314682/
https://ncbi.nlm.nih.gov/pubmed/25399844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201300257
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